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Effects Of Ethyl Cellulose & Hydroxy Propyl Methyl Cellulose Polymer On The Release Profile Of Diltiazem Hydrochloride Sustained Release Pellets | 7572
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
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Effects of ethyl cellulose & hydroxy propyl methyl cellulose polymer on the release profile of diltiazem hydrochloride sustained release pellets

2nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

Shahana Sharmin, Nuzhat Mariam Elias and Ishtiaq Ahmed

Accepted Abstracts: Pharmaceut Reg Affairs

DOI: 10.4172/2167-7689.S1.008

Abstract
In the present study, the effect of cellulose polymers Ethyl Cellulose & Hydroxy Propyl Methyl Cellulose, was evaluated on the release profile of drug from sustained release pellet. Diltiazem Hydrochloride, an antihypertensive, cardio protective agent and slow channel blocker was used as a model drug to evaluate its release characteristics from different pellets formulations. Diltiazem Hydrochloride sustained release pellets were prepared by drug loading (drug binder suspension) on neutral pellets followed by different percentages of spraying, i.e. 2%,4%, 6%, 8% and 10% coating suspension using ethyl cellulose & hydroxy propyl methyl cellulose polymer in a fixed 85:15 ratios respectively. The in vitro dissolution studies of Diltiazem Hydrochloride from these sustained release pellets were carried out in pH 7.2 phosphate buffer for 1,2,3,4,5,6,7 and 8 hrs using USP-I method. Statistically significant differences were found among the drug release profile from different formulations. Polymer content with highest concentration of Ethyl cellulose on the pellets shows highest release retarding rate of the drug. The retarding capacity decreases with the decreased concentration of ethyl cellulose. The release mechanism was explored and explained with zero order, first order, Higuchi and Korsmeyer?s equations. Finally the study showed that the profile and kinetics of drug release were functions of polymer type, polymer concentration & the physico chemical properties of the drug.
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