alexa Effects Of Exogenous Luteinizing Hormone On Patients With Relative LH Defi Ciency After Pituitary Down-regulation During Controlled Ovarian Hyperstimulation | 7184
ISSN: 2161-0665

Pediatrics & Therapeutics
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Effects of exogenous luteinizing hormone on patients with relative LH defi ciency after pituitary down-regulation during controlled ovarian hyperstimulation

International Conference on Pediatrics & Gynecology

Zhihong Niu, Yun Feng, Aijun Zhang, Yijuan Sun and Xiaowei Lu

Accepted Abstracts-2011: Pediatr Therapeut

DOI: 10.4172/2161-0665.S1.06

Abstract
Background: Th e eff ect of exogenous LH supplementation on ovarian stimulation parameters, as well as treatment outcome was evaluated in patients with relative LH defi ciency (serum FSH/LH ration≥3 on stimulation day 1 aft er pituitary down- regulation with a GnRH agonist) and ovarian stimulation with recombinant FSH (rFSH) during IVF/ICSI cycles. Methods: Th e patients with serum FSH/LH ration≥3 on stimulation day 1 aft er pituitary down-regulation with a GnRH agonist were randomly divided into two groups: group 1, using f-FSH alone and no hMG addition through the stimulation procedures (n=143) and group 2, receiving human menopause gonadotropin (hMG) supplementation from the 7 th day of stimulation (n=142). Treatment outcomes and relative hormone levels in both groups were compared. Results: Th ere ware no statistic diff erence on serum FSH, LH, E2 and progesterone level between two groups on baseline, stimulation day 1 and day 7. Patients in group 2, despite with fewer days of stimulation (9.6?0.8 vs. 9.9?1.1 P =0.009) and administering fewer amounts of total gonadotropin than group1 (30.6 ? 4.5 vs. 33 ? 4.1, P  0.001), have higher serum E2 concentration on HCG day compared to group 1( 2615?1196 versus 2248?1028pg/ml, P =0.006). Th e two groups gained almost the similar number of oocytes but group 2 gained higher number of viable embryos (4.3?1.4 versus 3.8?1.5, P=0.004). Further, compared to group1, group 2 had higher proportion of patients with serum E2 reaching 3000-4000pg/ml (30.8% versus 18.5%, P<0.05) and higher number of follicle with average diameter in range of 10-14 mm on hCG day (7.5?1.8 versus 6.3?2.0, P<0.05). No signifi cant diff erences ware found for other variables such as number of embryo transferred and pregnancy outcomes. Conclusions: In stimulation protocol with pituitary down-regulation by a GnRH agnist, exogenous LH addition by hMG from stimulation day 7 could increase ovarian response and improve embryo quality for patients with FSH/LH ≥3 on the fi rst day of ovarian stimulation.
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