ect of exogenous LH supplementation on ovarian stimulation parameters, as well as treatment outcome
was evaluated in patients with relative LH defi
ciency (serum FSH/LH ration≥3 on stimulation day 1 aft
er pituitary down-
regulation with a GnRH agonist) and ovarian stimulation with recombinant FSH (rFSH) during IVF/ICSI cycles.
e patients with serum FSH/LH ration≥3 on stimulation day 1 aft
er pituitary down-regulation with a GnRH agonist
were randomly divided into two groups: group 1, using f-FSH alone and no hMG addition through the stimulation procedures
(n=143) and group 2, receiving human menopause gonadotropin (hMG) supplementation from the 7
day of stimulation
(n=142). Treatment outcomes and relative hormone levels in both groups were compared.
ere ware no statistic diff
erence on serum FSH, LH, E2 and progesterone level between two groups on baseline,
stimulation day 1 and day 7. Patients in group 2, despite with fewer days of stimulation (9.6?0.8 vs. 9.9?1.1 P =0.009) and
administering fewer amounts of total gonadotropin than group1 (30.6 ? 4.5 vs. 33 ? 4.1, P
0.001), have higher serum E2
concentration on HCG day compared to group 1(
2248?1028pg/ml, P =0.006). Th
e two groups gained almost
the similar number of oocytes but group 2 gained higher number of viable embryos (4.3?1.4 versus 3.8?1.5, P=0.004). Further,
compared to group1, group 2 had higher proportion of patients with serum E2 reaching 3000-4000pg/ml (30.8% versus 18.5%,
P<0.05) and higher number of follicle with average diameter in range of 10-14 mm on hCG day (7.5?1.8 versus 6.3?2.0, P<0.05).
erences ware found for other variables such as number of embryo transferred and pregnancy outcomes.
In stimulation protocol with pituitary down-regulation by a GnRH agnist, exogenous LH addition by hMG from
stimulation day 7 could increase ovarian response and improve embryo quality for patients with FSH/LH ≥3 on the fi
of ovarian stimulation.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals