alexa Effects Of Pravastatin Or 12/15 Lipoxygenase Pathway Inhibitors On Indices Of Diabetic Nephropathy In An Experimental Model Of Diabetic Renal Disease | OMICS International
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

5th World Congress on Diabetes & Metabolism
November 03-05, 2014 Embassy Suites Las Vegas, USA

Hayam I Gad
Accepted Abstracts: J Diabetes Metab
DOI: 10.4172/2155-6156.S1.028
Objective: The present study aimed at attenuating the effects of early streptozotocin-induced diabetes on renal functions through supplementation of either pravastatin or 12/15-LO pathway inhibitors. Materials and methods: The current study was carried out on 88 male Wistar assigned to 3 groups (8 rats/group): Group I: included control rats receiving vehicle. Groups IIa, IIb, IIc, IId, IIe: included normoalbuminuric diabetic rats receiving vehicle, NDGA, NDGA + insulin, pravastatin or pravastatin + insulin respectively. Groups IIIa, IIIb, IIIc, IIId, IIIe included microalbuminuric diabetic rats receiving vehicle, NDGA, NDGA + insulin, pravastatin or pravastatin + insulin respectively. Renal function tests were measured and blood samples were analyzed for glycosylated hemoglobin (HbA1c), serum levels of cholesterol, triglycerides and lipid peroxide and plasma levels of VEGF, total nitric oxide (NO) products and homocysteine (Hcy). Results: The results of the present study demonstrated favorable effects of both NDGA and pravastatin to the same extent on renal functions and more favorable effects when diabetes is controlled. Microalbuminuri rats received NDGA experienced a decrease in urinary albumin creatinine ratio (ACR) to the same extent as did microalbuminuric rats received pravastatin. Indices of DN and oxidative stress as lipid peroxide, VEGF, and Hcy all were reduced by NDGA or pravastatin therapy with no statistical difference between the two lines of therapy. Conclusion: 12/15-LO inhibition and statins like pravastatin may be useful as therapeutic strategies for prevention or amelioration of DN. Confirmation of these preliminary observations must await careful long-term studies on experimental DN.
image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version