alexa Effects Of Selective PDE-2 Inhibitor BAY60-7550 And PDE-9 Inhibitor PF-04447943 On Olfactor Memory In Social Transmission Of Food Preference (STFP) Test In Naive Mice
ISSN: 2161-1459

Journal of Clinical & Experimental Pharmacology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

8th World Congress on Pharmacology and Toxicology
July 24-25, 2017 Melbourne, Australia

Furuzan Yildiz Akar, Emine Bektaş, Oguz Mutlu, Güner Ulak and Faruk Erden
Kocaeli University, Turkey
Posters & Accepted Abstracts: Clin Exp Pharmacol
DOI: 10.4172/2161-1459-C1-020
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic AMP (cAMP) and/or cyclic GMP (cGMP) throughout the body, including the brain. Accumulating evidence indicates that the inhibition of phosphodiesterase (PDE) activity may be a particularly interesting mechanism for memory enhancement. PDE inhibitors present a novel therapeutic approach with which to arrest cognitive decline or to possibly reverse this decline with cognitive enhancement. The aim of this study was to investigate effects of BAY 60-7550, a PDE2 inhibitor and PF-04447943, a PDE9 inhibitor on olfactory memory in naive mice using social transmission of food preference (STFP) test. Hippocampus-dependent non-spatial olfactory memory was studied using the STFP. In the STFP test, the ratio of the weight of the cued food eaten and the total weight of food eaten was used as a measure of food preference. Higher percentage of cued food/total food eaten reflects better performance in olfactory memory. BAY60-7550 (1 and 3 mg/kg) and PF-04447943 (1 and 3 mg/kg) (n=12 per group) were administered intraperitoneally 30 and 60 minutes, respectively before the retention session of STFP test. One way Anova post hoc Tukey’s test was used for the statistical analysis of the data. BAY 60-7550 and PF-04447943 significantly increased % cued food/total food eaten compared to the control group. BAY 60-7550 and PF-04447943 also decreased total food consumption compared to the control group but it was not significant. Our results confirm that BAY 60-7550 and PF-04447943 enhance olfactory memory of naive mice in the STFP test.

Füruzan Yildiz Akar has completed her PhD and Postdoctoral studies from Kocaeli University, School of Medicine, Turkey. Presently she is working as an Associate Professor at the Kocaeli University, School of Medicine. She has published more than 50 papers in english and has many poster presentations.


image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

1-702-714-7001Extn: 9042

General Science

Andrea Jason

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001Extn: 9042

© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version