alexa Effects Of Sleeve Gastrectomy With/without Omentectomy In Body And Metabolic Profile Of Diabetic Rats | OMICS International
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

5th World Congress on Diabetes & Metabolism
November 03-05, 2014 Embassy Suites Las Vegas, USA

Tha?sa Crespo, Jo?o Marcus Oliveira Andrade, Alanna Para?so Fernandes, Pablo Vinicyus Ferreira Chagas, Gislaine C?ndida Batista Jorge, Ant?nio S?rgio Barcala, Jorge and S?rgio Henrique Sousa Santos
Posters: J Diabetes Metab
DOI: 10.4172/2155-6156.S1.027
Abstract
Objective: To evaluate the physical and metabolic effects in rats treated with high fat diet (HD) and standard diet (SD) and underwent sleeve gastrectomy/vertical gastrectomy (VG) with and without omentectomy. Method: Analytical experimental study, using male Wistar rats that were randomized into six groups consisting of eight animals/each: SD+laparotomy (SD+L), SD+VG, SD+VG+omentectomy (SD+VG+O), HD+laparotomy (HD+L), HD+VG and HD+VG+omentectomy (HD+VG+O). The study was divided into two stages. First phase: Treatment for eight weeks with the respective diets. The high fat diet induced obesity, insulin resistance and type 2 diabetes mellitus. Second phase: Rats were submitted to surgical treatment and fed for four weeks with their respective diets. Throughout the treatment the body weight and food intake were measured (three times/week). At the end of the second phase, the animals were subjected to the insulin sensitivity test (IST). The sacrifice was made by decapitation to collect blood and mesenteric, retroperitoneal and periepididymal adipose tissues. Serum samples were used for biochemical analyzes: Total cholesterol, HDL, triglycerides, glucose, urea and creatinine. Data were analyzed using Graph Pad Prism 5.0, using tests of Two-Way ANOVA and One-Way ANOVA and Bonferroni post-test. Results: The results showed significant decrease in body fat between the following groups: SD+L vs. HD+L, SD+VG+O vs. HD+L and SD+VG+O vs. HD+VG+O. Dietary intake was shown to be increased in the SD+L and HD+L groups and decreasing the treatment groups after surgery. The IST indicated significant improvement in insulin sensitivity in groups HD+VG and HD+VG+O compared to HD+L. Regarding plasma analyzes, the results indicated a significant decrease in total cholesterol levels between HD+L vs. HD+VG and HD+L vs. HD+VG+O. HDL levels did not differ between groups. The results also indicated a tendency of decrease in the levels of triglycerides and glucose in groups HD+VG and HD+VG+O vs. HD+L, but no statistical association. Similar results were observed for levels of urea. Statistically significant association was observed between HD+L vs. SD and HD groups submitted to surgical treatment regarding the levels of creatinine. Conclusion: The study demonstrates beneficial effects of VG with respect to loss of total adiposity and weight, total cholesterol and creatinina levels and improves insulin sensitivity in rats treated with high fat diet and can thus be considered a therapeutic option in the treatment of obesity and its comorbidities. More studies are needed to confirm whether omentectomy would have beneficial effects associated with VG.
image PDF   |   image HTML
 

Relevant Topics

OMICS International Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version