Effi cient drug carrier nanofi bers contained PEG-POSS loading insulin nanoparticles for oral delivery of protein drugs

2^nd World Congress on Biomarkers & Clinical Research

12-14 September 2011 Baltimore, USA

Kyu Oh Kim, Byoung-Suhk Kim, Ick Soo Kim

Posters: J Mol Biomark Diagn

Abstract :

I n a recent year, nanotechnology has been utilized to develop new therapies and next generation nanosystems for ?smart? drug delivery. A variety of organic/inorganic nanomaterials and devices have been oft en used as delivery vehicle to enhance the therapeutic activity by prolonging drug half-life, improving solubility of hydrophobic drugs, reducing potential immunogenicity, and/or releasing dugs in a sustained or stimuli-t riggered fashion. Current treatment methods involve regular injections of insulin, which can be both painful and inconvenient, thus leading to low patient compliance. In order to overcome this problem, the oral route is considered to be the most convenient and comfortable means of drug administration for patients. In this work, novel drug carrier nanofi bers with core-shell poly(ethylene glycol) (PEG)-polyhedral oligosilsesquioxane (POSS) nanoparticles were used to encapsulate insulin as new drug delivery carriers via electrospinning. Th e morphologies of fi ber and particles, particle size and  potential of the pure nanostructured core-shell PEG-POSS and the corresponding insulin- loaded PEG-POSS nanoparticles were investigated by transmission electron microscopy (TEM) and laser diff raction particle sizer. Insulin release test showed that insulin was well-protected inside PEG-POSS nanoparticles at gastric pH for 2hrs, and was released at intestinal pH (pH 6-7) where the absorption and activation of the drug are necessary. We therefore believe that such nanofi bers contained PEG-POSS nanoparticles could be useful as a potential carrier for insulin drug delivery systems

Biography :

Ms. Kyu Oh Kim have joined at department of Bioscience and Textile Technology, Nano Fusion Technology Research Group, Shinshu University at Japan, since 2009- now as a Doctor?s degree (Advisor: Prof. Ick- Soo Kim). Her research interests are ?Biocompatible Organic/inorganic nano fi ber using a polyhedral oligosilsesquioxane (POSS) and designing the fi brous scaffolds for tissue engineering application?. She received her bachelor and master degree in polymer system engineering from Dankook University at Korea in 2009 (Advisor: Prof. Kee-JongYoon