alexa Efficacy Of Different Perioperative Statin Regimens On The Protection Against Post Coronary Artery Bypass Grafting Major Adverse Cardio-cerebral Events
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Joint Conference on 17th European Heart Disease and Heart Failure Congress and 2nd International Conference on Cardiovascular Medicine and Cardiac Surgery
March 15-17, 2017 London, UK

Aya Elmarsafawi
Cairo University, Egypt
Posters & Accepted Abstracts: J Clin Exp Cardiolog
DOI: 10.4172/2155-9880.C1.066
Abstract
Statement of the Problem: CABG is an effective palliative treatment for IHD patients. Nevertheless, CABG patients are at a high risk of developing postoperative major adverse cardio-cerebral events (MACCE). Statins have proven safe and effective at improving short and long-term outcomes after CABG. However, an optimal pre and postoperative statin regimen that would efficiently protect CABG patients from postoperative adverse events is still ambiguous and needs to be further investigated prospectively. Aim: This study aims at comparing three different perioperative statin regimens to find out the best regimen that is safe and effective at providing maximal protection from post CABG adverse events. Methodology & Theoretical Orientation: 94 patients scheduled for elective, isolated on- or off- pump CABG were randomly assigned to one of three treatment groups; group I (80 mg atorvastatin/day for 2 days preoperatively (N=37)), group II (40 mg atorvastatin/ day for five to nine days preoperatively (N=29) or group III (80 mg atorvastatin/day for five to nine days preoperatively (N=28)). The corresponding preoperative regimens were restarted postoperatively and were continued for one month. Troponin I, CK-MB and CRP were assayed preoperatively and at 8, 24, 48 hours postoperatively and at discharge. Time course of changes of marker levels across these time points were compared. The incidence of post-op MACCE was assessed. A quality of life questionnaire (EQ-5D-3L) was administered preoperatively and one month after CABG. Results: There was no significant difference among the three treatment groups in the incidence of postoperative MACCE, length of hospital stay, infections, renal and hepatic impairment. CRP levels were significantly lower in group III compared to the two other groups. However, troponin I levels were significantly lower in group II compared to group III. The QoL questionnaire showed an overall significant improvement after CABG in the three regimens.
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