Siavash M Shanehsaz
Kerman University of Medical Sciences, Iran
Posters & Accepted Abstracts: J Cosmo Trichol
Background: Melasma is a common acquired disorder characterized by symmetric, hyperpigmented patches with an irregular outline, occurring most commonly on the face. The goal of this study was to evaluate the skin-lightening ability and tolerability profile of a novel formulation, cream solid lipid nanoparticles containing licorice extracts in the treatment of Melasma. This study to our knowledge is the first to show the efficacy of this novel formulation in the treatment of melasma all over the world. Methods: In this randomized, double-blinded and placebo-controlled clinical trial, 44 women patients with melasma clinically diagnosed referred to the Afzalipour hospital clinic were randomly divided into two treatment groups of 22 subjects each. All the patients were visited every four weeks from the beginning of the trial and evaluated MMASI score at 4, 8 and 12 weeks. The effectiveness of the treatment was classified in four levels as complete response, significant response, partial response and no response. Results: Forty women patients were enrolled in the study. At the end of the study (12 weeks), diminution of MMASI score was from (11.03�±2.7) to (1.41�±0.6) in intervention group and from (11.25�±2.9) to (2.37�±1.2) in control group, respectively (P<0.001). Conclusions: Licorice extracts can be used as a skin-lightening agent with minimal side effect in the treatment of melasma. Nano/ micro solid lipid particles is used as carriers with unique properties like size, surface electrical bar and moreover, a large amount of the drugs might be loaded to interplay a better performance in terms of adverse drug reactions considered drug.
Email: mdsiavash@yahoo.com
Journal of Cosmetology & Trichology received 180 citations as per Google Scholar report
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