Journal of Chromatography & Separation Techniques
Open Access
ISSN: 2157-7064
+44 1300 500008
ISSN: 2157-7064
+44 1300 500008
Koichi Tanaka
Kansai University, Japan
Posters & Accepted Abstracts: J Chromatogr Sep Tech
Porous metal-organic frameworks (MOFs) have attracted much attention in the last decade because they can be used for various potential applications such as gas storage, separation, sensing, and catalysis. Recently, MOFs have been considered as separation materials for chromatography owing to their high surface area, uniform structural cavities, outstanding thermal and chemical stability, and selective adsorption phenomena. To date, a number of chiral MOFs have been developed and synthesized. Chiral MOFs have great potential as chiral stationary phases (CSPs) for HPLC enantioseparation of racemic compounds. However, there are only a few attempts of chiral MOFs being used in liquid chromatographic enantioseparation; most of which exhibited a relatively narrow range of chiral enantioselectivity. Herein, we report novel homochiral pillared MOFs (1, 2) with excellent selectivity for HPLC enantiomeric separation of various racemates such as sulfoxides, sec-alcohols and flavanones. The racemates of sec-alcohols were well separated on both the MOF-1 and MOF-2 columns. The separation factors (ï¡) were also larger for p-substituted derivatives than for their o- and m-substituted counterparts, which is most likely because of steric constraints. Interestingly, the introduction of electronwithdrawing substituents on the aromatic ring gave rise to a prominent base-line separation of enantiomers as shown in Figure 1. The Ï�?-Ï�? interactions between the N-donor linker of the framework and electron-deficient aromatic group of compound may be one of reasons.
Email: ktanaka@kansai-u.ac.jp