alexa Efficient Inhibition Of HIV Replication By Targeting 3UTR Transcripts Using New Modified MiR-30a
ISSN: 1948-5964

Journal of Antivirals & Antiretrovirals
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

4th World Congress on Virology
October 06-08, 2014 Hilton San Antonio Airport, TX, USA

Ahmad Nejati, Shohreh Shahmahmoodi, Zabihollah Shoja and Sayed-Mahdi Marashi
Posters: J Antivir Antiretrovir
DOI: 10.4172/1948-5964.S1.021
RNA interference (RNAi) based gene therapy has currently been considered as a combinational anti-HIV-1 therapy. While artificial polycistronic microRNAs can reduce HIV-1 escape mutants, this approach causes cell toxicity by saturation of endogenous RNAi machinery. This study aimed to optimize the efficiency of RNAi gene therapy in order to reduce cell toxicity. We explored an artificial miR-30a-3?UTR (miR-3?UTR) from a single RNA pol II expressed transcript that targets simultaneously all viral transcripts. We constructed a pre-miR-30a backbones encoding siRNAthat targets the HIV-1 3?UTR. Our data indicated thatHIV-1 replication was significantly inhibited in the cell culture using miR-3?UTR construct, suggesting a promising tool for consideration of RNA-based gene therapy application.
image PDF   |   image HTML
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version