Reach Us +44-1235-425476
Ei24-mediated Regulation Of PKCa Contributes To Carcinogenesis Of Skin Cancer | 3028
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Ei24-mediated Regulation of PKCa Contributes to Carcinogenesis of Skin Cancer

2nd International Conference on Pharmaceutics & Novel Drug Delivery Systems

Han-Woong Lee

Posters: Pharm Anal Acta

DOI: 10.4172/2153-2435.S1.09

Etoposide-induced gene 24 (Ei24) is a p53 target gene that inhibits growth, induces apoptosis and autophagy, as well as suppresses breast cancer. To evaluate the role of Ei24 in in vivo tumorigenesis, we generated an Ei24-deficient mouse model. Here, we report that, although Ei24 homozygous knockout mice are embryonic lethal, Ei24 heterozygous null mice are resistant to DMBA/TPA-inducedcarcinogenesis of squamous cell carcinoma due to defective STAT3 and PKCα signaling. Ei24 containsa functional consensus motif, named as an R motif that ishighly analogous to amino acids105-110 of RINCK1, an E3 ligase for protein kinase C (PKC) proteins.We foundthat Ei24stabilizesPKCα via RINCK degradation and competition with RINCK for binding with the C1a domain of PKCα. We also found that Ei24contributes to PKCα-mediated transactivation of EGFR by promoting PKCα membrane localization and interaction with EGFR leading to STAT3 activation. These results suggest that Ei24 is a critical regulator of the PKCα-EGFR-STAT3 signaling pathway in the development of skin cancer.
Professor Han-Woong Lee is in the Department of Biochemistry at Yonsei University, Seoul, South Korea. He is the leading mouse geneticist in the country and is the director of Yonsei Laboratory Animal Research Centre (YLARC). In YLARC, knock-out and transgenic mouse models of various genes relevant to human health are being produced.