alexa Elevated P53 Protein Expression Could Be A Predictor Of Early Relapse After Hematopoietic Stem Cell Transplantation In Children With Acute Myelogenous Leukemia
ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd International Conference on Hematology & Blood Disorders
September 29-October 01, 2014 DoubleTree by Hilton Baltimore-BWI Airport, USA

Britt Gustafsson
Keynote: J Blood Disorders Transf
DOI: 10.4172/2155-9864.S1.005
Abstract
Background: Dysregulation of genes involved in the cell cycle such as TP53, P21, P16 and PTEN play a key role in oncogenesis. We have earlier reported an increased expression of the TP53 encoded protein p53, in bone marrow samples from pediatric patients with more aggressive myelodysplastic syndromes. The aim of this study was to investigatethe protein expression of the cell cycle regulating proteins p53, p21, p16 and PTEN before and after hematopoietic stem cell transplantation (HSCT) in pediatric patients with acute myelogenous leukemia (AML) and evaluate if any potential alterations could predict relapse after HSCT. Procedure: Paraffin embedded bone marrow samples from 34 pediatric patients with AML were collected retrospectively from time of diagnosis and pre- and post HSCT. Immunohistochemistry was performed on tissue microarrays with antibodies against p53, p21, p16 and PTEN. Study material was analyzed by non-linear regression and independent T-tests, and a time- to-event analysis was conducted. Results: The non-linear logistic regression did not significantly predict for relapse at any time point for any of the proteins investigated, but T-tests showed a statistical significant difference in p53 (p=0.010) and p16 (p=0.028) with overexpression in the group of patients who relapsed compared to the relapse-free patients at 6 months post HSCT. Conclusion: Elevated p53 protein expression was found at all time points in the AML relapse group compared to the relapse- free patients, with a significant difference at 6 months post HSCT, indicating that p53 and p16 could be used as a prognostic marker at that time.
Biography
Britt Gustafsson has completed her PhD 15 years ago from Karolinska Institutet and has continued her studies in the field of pediatric hematology. She has published more than 60 papers in the field of pediatric hematology. She is a senior pediatric consultant at Center for Allogeneic Stem Cell Transplantation at Karolinska University Hospital. She has also worked as a pediatrician at a smaller mission hospital in Zambia for the last 4 years.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords