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Elevation In Liver Function Marker (alanine Aminotransferase) And Plasma Metabolites With Aging | 43854
ISSN: 2153-0769

Metabolomics:Open Access
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Elevation in liver function marker (alanine aminotransferase) and plasma metabolites with aging

5th International Conference and Exhibition on Metabolomics

Minjoo Kim, Minkyung Kim, Hye Jin Yoo, Miso Kang and Jong Ho Lee

Yonsei University, Korea

Posters & Accepted Abstracts: Metabolomics

DOI: 10.4172/2153-0769.C1.032

The aim of this study was to identify age-related metabolite changes associated with elevated serum alanine aminotransferase (ALT) and to explore possible underlying mechanisms. The study included 602 healthy, nondiabetic subjects (aged 30−65 years); 393 individuals had normal ALT levels at baseline. Fifty individuals developed elevated ALT levels after 3 years. The remaining 340 subjects with normal ALT were matched to the elevated-ALT group (n=50) for age, gender, BMI, fasting glucose, and ALT to form the control group (n=50). At the 3-year follow-up, the elevated-ALT group exhibited greater increases in waist circumference, free fatty acid, ALT, aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), bilirubin, oxidized LDL, Lp-PLA2 activity, urinary 8-epiprostaglandin F2α (8-epi-PGF2α), and brachial-ankle pulse-wave velocity (ba-PWV) compared to the control group after adjusting for baseline. The elevated-ALT group exhibited greater increases in plasma L-valine (q=0.014), L-leucine (q=0.007), L-phenylalanine (q=0.006), and decanoylcarnitine (q<0.001). Mean ALT levels increased in a linear fashion with increasing changes in these four metabolites, which correlated with changes in AST, GGT, Lp-PLA2 activity, urinary 8-epi-PGF2α, and ba-PWV. Mean ALT changes did not significantly correlate with HOMA-insulin resistance. These findings suggest that increased plasma levels of L-valine, L-leucine, Lphenylalanine, and decanoylcarnitine precede insulin resistance during periods of elevated ALT and occur in conjunction with enhanced risk factors for cardiovascular disease, such as Lp-PLA2 activity, oxidative stress, and arterial stiffness.

Minjoo Kim has completed her PhD from Yonsei University. She is currently a Postdoctoral student in Research Center for Silver Science, Yonsei University. Her researches are focussed on medical nutrition therapy in metabolic diseases, aging, nutrition-related metabolomics, etc. She has published more than 24 papers in reputed journals and has registered 2 patents (also, 9 patent applications).

Email: [email protected]