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|Xu-ri Huang, Lu Liu, Xian-yang Zeng and Xi Zhao|
|Jilin University, China|
|Posters & Accepted Abstracts: J Chem Eng Process Technol|
|Acid-sensing ion channel 1a(ASIC1a) as proton-activated receptor cation channel, contributes to sensory transduction, depression and fear-related behaviors throughout nervous system. So far, how proton mediates the channel gating process still remains elusive. Here we report that the ion pore changes at different PH values through molecular dynamics (MD) simulations. The path of long-range conformational changes from the extracellular domain to the transmembrane domain was determined; further, the correlation network analysis reveals how the interactions between subunits influence the channel gating changes. β1, β2, β10, α6, α7, β11 and β12 are the crucial regions by forming a passageway to regulate the ion pore changes. Our results reveal the process that the extracellular domain remotely regulates the pore changes.|
Xu-ri Huang has completed his PhD in 1991 from Jilin University. Now He is a professor of Institute of Theoretical Chemistry, Jilin University. His research focuses on theoretical chemistry, such as catalysis reaction mechanism and biomolecular simulation. He has published more than 150 papers in reputed journals.
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