alexa Emap-II-induced Immune Suppression In Colorectal Cancer
ISSN: 2471-9552

Immunotherapy: Open Access
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Conference on Tumor & Cancer Immunology and Immunotherapy
July 17-18, 2017 Chicago, USA

Manal Mohamed Saber and Matthias Clauss
Minia University, Egypt
Indiana University School of Medicine, Indianapolis, Indiana
ScientificTracks Abstracts: Immunotherapy (Los Angel)
DOI: 10.4172/2471-9552-C1-005
Abstract
Statement of the Problem: Colorectal cancer (CRC) is being currently considered one of the most common and deadly malignancies in the world. Many CRC patients are likely to be immunosuppressive. Endothelial monocyte-activating polypeptide-II (EMAP-II) is a multifunctional cytokine with pro-inflammatory properties. It was demonstrated that EMAP-II induces lymphocytes apoptosis in CRC. The purpose of this study is to investigate the role of EMAP II in immune suppression in CRC. Methodology & Theoretical Orientation: The immunosuppressive effect of EMAP-II was verified by in vivo and in vitro experiments. The immunosuppressive mechanisms were analysed using flow cytometry, ELISA, immunohistochemistry and T-lymphocytes assays. Findings: EMAP-II expression in CRC was associated with suppression of T-cell activity and decreased infiltrating T-cells. EMAP-II blockade in mice bearing colorectal cancer reduced tumour burden and increased T-cell responses. In this study, we found that colorectal cancer-infiltrating tregs expressed increased levels of EMAP-II. Furthermore, EMAP-II levels correlated positively with serum IL-2 and TGF-β (p<0.001). Conclusion & Significance: This study has demonstrated the role of EMAP-II in immune suppression and the potential for immunotherapy via blocking EMAP-II in CRC.
Biography

Manal Mohamed Saber has completed her PhD from Nottingham University, UK. She is an Associate Professor of Clinical Pathology, Minia University, Egypt. She has published papers in peer reviewed journals and has been serving as an Editorial Board Member of others. She has interests in cancer studies, immunotherapy and tumor immunology

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version