Endothelial Micro-particles In Patients With Chronic Kidney Disease And Cardiovascular Disease | 49095
Journal of Clinical & Experimental Cardiology
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Introduction: Chronic kidney disease is characterized by loss, normally gradual and progressive, of the excretory capacity by kidneys
and constitutes a serious public health problem and higher rate of cardiovascular events as acute myocardial infarct, stroke and
mortality when compared to the general population. Endothelial micro-particles are shed by the membrane of different cell types
after activation or apoptosis and are related to classic risk factors and cardiovascular disease.
Objective: Evaluate if the progression of kidney disease is related to the increase in circulating endothelial micro-particles, in patients
with established cardiovascular disease.
Methods: Some variables related to kidney disease (urine and serum creatinine, albumine/creatinine relation, glomerular filtration
rate) were correlated with endotelial micro-particle levels, in patients with cardiovascular disease (n=84), comparing the values
obtained to micro-particles according to the stage of kidney failure.
Results: There were no significant correlations between the parameters evaluated (correlation between endothelial micro-particles
and serum creatinine [Spearman, rho = -0,208; p = 0,064]; correlation between endothelial micro-particles and glomerular filtration
rate [Spearman, rho = 0.194, p = 0.085]), other correlations also not significant.
Conclusion: There was no evidence concerning the increase of endothelial micro-particles related to the progression of kidney
disease in patients with cardiovascular disease.
Carolina Nunes França has completed her PhD from Federal University of Sao Paulo, Brazil and Post-doctoral studies from University of Bonn, Germany. She is Professor of University of Santo Amaro – UNISA (Health Science Post Graduation), Brazil. She has published more than 36 papers in reputed journals.