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Enhanced Oral Bioavailability Of Poorly Water Soluble Drug Via Self-Microemulsifying Drug Delivery System (SMEDDS) | 8271
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
Open Access

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Enhanced oral bioavailability of poorly water soluble drug via Self-Microemulsifying Drug Delivery System (SMEDDS)

2nd World Congress on Bioavailability & Bioequivalence: Pharmaceutical R & D Summit-2011 and International Conference on Pharmaceutics & Novel Drug Delivery Systems

Akash Chaurasiya

Special Issue BABE-2011: Posters: JBB

DOI: 10.4172/0975-0851.1000105

B icalutamide is a novel, orally active, non-steroidal anti-androgens used for the treatment of prostate cancer. But its limited aqueous solubility leads to high variability in absorption aft er oral administration. To enhance the solubility and bioavailability of bicalutamide a novel nanocarriers system i.e. self-microemulsifying drug delivery system (SMEDDS) has been successfully developed. Solubility of bicalutamide was determined in various oils, surfactant and co-surfactant. On the basis of solubility studies, various SMEDDS formulations were prepared and ternary phase diagrams were plotted to identify the effi cient self-emulsifi cation region. Once the microemulsion region was identifi ed, SMEDDS at desired component ratios was prepared with bicalutamide (50 mgml-1). Th e formulation was then subjected to further characterization by dilution studies, droplet size, zeta potential and transmission electron miscroscopy (TEM). To investigate the release pattern of bicalutamide from SMEDDS, an in-vitro drug release study was done using USP dissolution apparatus in diff erent dissolution media and compared with the release of bicalutamide from a conventional tablet. Oral pharmacokinetic study was performed in female Wistar rats (n=8) at the dose of 25 mg kg−1. Th e absorption of bicalutamide from SMEDDS form resulted in about 2.2-fold increase in bioavailability compared with the conventional tablet dosage form. Our studies illustrated the potential use of SMEDDS for the enhancement of bioavailability of hydrophobic compounds, such as bicalutamide and encourage further development of bicalutamide loaded SMEDDS as an oral drug delivery system
Akash Chaurasiya had completed B. Pharm and M.Pharm (Pharmaceutics) from Department of Pharmaceutical Sciences, Dr H. S. Gour University Sagar (M.P.), India in the years 2004 and 2007 respectively. He has also quali fi ed GATE-2004 with percentile score of 92.72, conducted by IIT Delhi and received UGC Junior Research Fellowship for pursuing his M. Pharm degree. After the completion of post graduate studies he worked as a research scientist for 1 year in Dabur Research Foundation, Ghaziabad a renowned pharmaceutical company in India. In May 2008, Mr. Chaurasiya has joined PhD programme in pharmaceutical sciences under the guidance of Prof. R. K. Khar in Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi. During the PhD research work he was selected for Federal Commission Scholarship programme provided by Swiss Government, under which he was able to pursue a part of his PhD work from School of Pharmaceutics and Biopharmaceutics, University of Geneva, Switzerland for the time period of 9 months, from Sept.?09 to June?10. Presently, he has joined back Hamdard University, India and working as a senior research fellow for the completion PhD thesis work. Mr. Chaurasiya has an experience of approximately 5 years in pharmaceutical research and his areas of scienti fi c interest are: ? Oral bioavailability enhancement of active moieties which belongs to BCS class II & IV ? Site speci fi c targeting of anticancer drugs using biomolecules for better ef fi cacy and low toxicity ? Delivery of bio-therapeutics via ocular route Mr. Chaurasiya has published four research articles in reputed international research journals and attended a number of national and international conferences. He has also co- authored a book entitled ?Pharmaceutics-II? which was awarded as a best pharmacy book in hindi language by All India Council for Technical Education (AICTE), India.
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