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ceclofenac is a poorly water-soluble, new generational non-
steroidal anti-inflammatory drug. The aim of the present work
was to investigate and compare the effect of PVP K-30 and PVP/VA
64 as carriers on
dissolution characteristics of aceclofenac.
Aceclofenac solid dispersions were prepared by fusion method.
All the prepared solid dispersions exhibited appropriate yield,
average particle size, drug content, wetting time and moisture
content. Scanning electron microscopy indicated the amorphous
nature of the drug in the prepared formulation. The carriers did not
show any incompatibility when tested using Fourier transform infrared
spectroscopy and differential scanning calorimetry. A higher release
in both, 0.1 N HCl, pH 1.2 and phosphate buffer, pH 7.4 was observed
as compared to pure drug and their corresponding physical mixtures.
With perspective of the dissolution media, the phosphate buffer,
pH 7.4 showed higher dissolution as compared to 0.1 N HCl, pH 1.2.
The highest improvement in dissolution was found with PVP K-30
as carrier. The
release from all the formulations was best
described by first order kinetics (R
= 0.9354 and 0.9268 in 0.1N HCl and
phosphate buffer, respectively) followed by Higuchi release model (R
= 0.9029 and 0.9578 in 0.1N HCl and phosphate buffer, respectively)
with better intestinal absorption, analgesic and anti-inflammatory
< 0.05). The intestinal absorption followed the first order
= 0.9408). With enhanced solubility and dissolution, it
is expected that aceclofenac in solid dispersions will demonstrate
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