Enhancement of dissolution and stability of candesartan cilexetil-loaded silica polymers

21^st Annual European Pharma Congress

May 20-22, 2019 | Zurich, Switzerland

Mai Khanfar, Bashar Altaani and Eman Mohamaad

Jordan University of Science and Technology, Jordan

Posters & Accepted Abstracts: Pharmaceut Reg Affairs

Abstract :

Objective: To prepare stable amorphous solid dispersions of candesartan cilexetil (CAN) with different types of silica, including non-porous (aerosil 200) and porous silica (sylysia 350) using the spray-drying method.

Methods: various ratios of candesartan cilexetil (CAN) were spray dried with aerosil and sylysia. Powder x-ray diffraction (x-ray) differential scanning calorimetry (DSC), SEM were used to characterize the spray dried powders in addition to dissolution and stability studies.

Results: X-ray results showed that the sprayâ??dried (CAN) in the prepared solid dispersion were in amorphous form irrespective of the used silica. In (DSC) analysis, the melting peak of spray-dried (CAN-silica) solid dispersion disappeared. Dissolution property of (CAN) was remarkably improved by formulating with silica particles. In comparing the effect of the type of the silica particles, the dissolution rate of (CAN) from the spray-dried (CANsylysia) was faster than that (CAN-aerosil 200) irrespective of the drug content. It was also shown that the spraydried formulation with silica did not recrystallize when storing at severe storage conditions (40 °C, 75% RH) for three months, while spray-dried (CAN) without silica easily re-crystallized under the same conditions.

Conclusion: Spray drying of (CAN) with sylysia 350 is an efficient method to enhance the dissolution and stability of the drug.

Recent Publications

1. Khanfar, M etal (2019) enhancement of dissolution and stability of Candesartan cilexetilâ??loaded silica polymers(2019) IJAP,

2. Khanfar,M,etal (2018) Enhancement of the dissolution and bioavailability from freeze-dried powder of a hypocholesterolemic drug in the presence of Soluplus., Powder Technology 329:25-32

3. Khanfar, M and Suhair ALnimry (2017),Stabilization and Amorphization of Lovastatin Using Different Types of Silica,AAPSPharmSciTech 18(6

4. al Nimry, Suhairand Khanfar M.2015,Preparation and characterization of lovastatin polymeric microparticles by coacervation-phase separation method for dissolution enhancement, Journal of Applied Polymer Science 133(14)

5. Khanfar M., Fares M, Salem M, Qandil A., 2013, Mesoporous silica based macromolecules for dissolution enhancement of Irbesartan drug using pre-adjusted pH method, Microporous and Mesoporous Materials 173:22-28.