Modern Chemistry & Applications

Enzymatic synthesis of steryl glycosides and their anticancer therapeutic applications

9^th Global Chemistry Congress

July 23-24, 2018 | Lisbon, Portugal

Tung-Kung Wu

National Chiao Tung University, Taiwan

Posters & Accepted Abstracts: Mod Chem Appl

Abstract:

Steryl glycosides consist of a sterol/steroid aglycone and one or more sugar moieties linked through an ether or ester bond. Diverse biological activities including: anti-inflammatory, anti-fungal, anti-microbial, anti-parasitic and anti-tumor activities, and properties such as, cell membrane modification, regulation of host defenses against pathogens, lipid metabolism, and developmental events, have been attributed to this family of natural products. Development of structural diverse steryl glycosides may hold potential to identify candidates for new drug development and pharmaceutical applications. In this study, we functionally express different glycosyltransferases for in vitro synthesis of steryl glycosides with ??�- or ??�-configuration specificity. The synthesized steryl glycosides were investigated for their anticancer activity. Interestingly, several steryl glycosides show dose-dependent depression of cell viability and enhanced drug effectiveness on MCF-7 breast cancer cells. The structurereactivity relationships of these glycosyltransferases on substrate�????donor specificities and mode of action of steryl glycosides on anticancer activity will be discussed.

Biography :

Tung-Kung Wu has completed his PhD degree in Biophysics from the Johns Hopkins University and Post-doctoral studies in Chemistry Department from Stanford University. He is appointed as a Professor in the Department of Biological Science and Technology at the National Chiao Tung University. His research interests include interdisciplinary fields of Bioorganic Chemistry, Chemical Biology, and Medicinal Chemistry. His current research interests mainly focus on the structurereactivity relationships of glycoenzymes and mode of action of steryl glycosides as drug candidates.

E-mail: tkwmll@mail.nctu.edu.tw