Pharmaceutica Analytica Acta

E-Pharmaceutica- lipid digestion media (lipolysis) an effective tool for the prediction of fate of the drug in gastrointestinal tract from lipid based drug delivery system

5^th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

March 16-18, 2015 Crowne Plaza, Dubai, UAE

R Suresh Kumar

Posters & Accepted Abstracts: Pharm Anal Acta

Abstract:

Nanoemulsion preparation was optimized initially by performing solubility study of the drugs atorvastatin, fenofibrate and olanzapine in different oils. From the solubility studies, the oil in which the drug showed maximum solubility is oleic acid for atorvastatin and capryol90 for fenofibrate and olanzapine. Nanoemulsions were formulated and subjected to lipolysis study. The fate of drug in GIT was estimated by in vitro lipolysis model. Precipitation of atorvastatin with oleic acid was observed which indicated that the lipid phase is not suitable for nanoemulsion formulation of the drug. Hence the oil which showed the next highest solubility of atorvastatin was selected and NE was formulated, which showed no sign of precipitation during lipolysis analysis and about 96.84% of drug in the aqueous layer, indicating that the lipid phase is suitable for nanoemulsion formulation of the drug. The lipolysis study of fenofibrate and olanzapine in capryol 90 showed no sign of precipitation about 88% and 92.28% of drug in the aqueous layer at the end of lipolysis for fenofibrate and olanzapine respectively, which indicated that the lipid phase is suitable for nanoemulsion formulation of respective drugs. Those formulations which passed the thermodynamic stability tests and dispersibility tests were subjected to droplet size analysis, PDI and zeta potential. The formulations with formulation code 8 with 25% oil (labrafac lipophile) solubulized by 32% SCoS and formulation code 16 with 25% oil (capryol 90) solubilized by 43.75% SCoS could be selected for drug incorporation and in vitro and in vivo studies.