Epigenetic Changes In Human Cells In Response To Chronic Citalopram Treatment | 19539
Journal of Molecular and Genetic Medicine
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To test the hypothesis that commonly-used pharmaceutical drugs might cause epigenetic changes, Human hN2 neurons
and HEK-293 cells were cultured in the presence of 10 μM citalopram for 10 days and genome-wide epigenetic analysis
was subsequently performed using Illumina?s Infinium Human Methylation 450 Bead Chip arrays. DNA methylation changes
were detected in numerous genes and non-coding regions compared to controls.
Antonei B Csoka completed his PhD at the University of Debrecen, Hungary, and Postdoctoral studies at Brown University and the University of Pittsburgh, USA.
His work is focused on epigenetics and it?s applications to human health.
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