alexa
Reach Us +44-1522-440391
Epithelial-mesenchymal Communication: New Paradigm In Fibroblast Activation And Kidney Fibrosis | 4316
ISSN: 2161-0959

Journal of Nephrology & Therapeutics
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Epithelial-mesenchymal communication: New paradigm in fibroblast activation and kidney fibrosis

International Conference and Exhibition on Nephrology & Therapeutics

Youhua Liu

ScientificTracks Abstracts: J Nephrol Therapeut

DOI: 10.4172/2161-0959.S1.004

Abstract
R enal fibrosis is the common final outcome of almost all progressive chronic kidney diseases (CKD). Because activated fibroblasts are the principal cells that are responsible for excessive production of extracellular matrix, elucidation of their origins, activation and regulation in injured kidney will be essential for providing mechanistic insights into the patho- mechanisms of CKD as well as for developing novel strategies for therapeutic intervention. As the major constituent of renal parenchyma, tubular epithelium is susceptible to a variety of metabolic, immunologic, ischemic and toxic insults, and is the primary target of kidney injury. Exactly how an injured tubular epithelium communicates with interstitial fibroblasts and causes them to undergo phenotypic activation is a central question. We recently uncovered a critical role for sonic hedgehog (Shh) and Wnt signaling in mediating such an epithelial-mesenchymal communication (EMC) in renal fibrogenesis. Shh was induced in tubular epithelium, but not in fibroblasts, in the fibrotic kidneys. However, Shh targeted fibroblasts, causing their proliferation and activation. Interestingly, upon stimulation by Shh, fibroblasts secreted a variety of Wnt ligands, which resulted in β-catenin activation in tubular epithelium. Furthermore, either inhibition of Shh signaling by cyclopamine or Wnt/β-catenin signaling by ICG-001 ameliorated renal fibrosis in obstructive nephropathy and adriamycin nephropathy. These results suggest that Shh and Wnt/β-catenin mediate a two-way communication between tubular epithelium and interstitial fibroblasts, thereby creating a vicious cycle that leads to uncontrolled fibroblast activation, matrix production and renal fibrosis
Biography
Dr. Youhua Liu obtained his PhD in cell biology from the Peking Union Medical College in Beijing, China. After receiving his postdoctoral training at NIH and the University of Pittsburgh, he joined the faculty at Brown University as an Assistant Professor of Medicine. He is currently a Professor of Pathology at the University of Pittsburgh School of Medicine. Dr Liu?s research is focused on dissecting the cellular and molecular pathways that lead to chronic kidney fibrosis, and exploring novel strategies for therapeutic intervention
Top