alexa Eravacycline, A Novel Fluorocycline, Is Highly Efficacious In Treating Tularemia And Anthrax In Animal Models
ISSN: 2155-9597

Journal of Bacteriology & Parasitology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

2nd International Congress on Bacteriology & Infectious Diseases
November 17-19, 2014 DoubleTree by Hilton Hotel Chicago-North Shore, USA

Joyce A Sutcliffe
ScientificTracks Abstracts: J Bacteriol Parasitol
DOI: 10.4172/2155-9597.S1.006
Eravacycline (ERV) is being developed as a broad-spectrum antibiotic for use as empiric monotherapy for the treatment of serious and life-threatening multidrug-resistant (MDR) Gram-negative and Gram-positive bacteria. A Phase 2 clinical trial evaluated the intravenous (IV) administration of ERV versus ertapenem for the treatment of patients with complicated intraabdominal infections (cIAI). ERV had similar cure rates to standard-of-care comparator ertapenem and a strong safety profile. Two global phase 3 trials are ongoing, one for the treatment of cIAI and a second to evaluate IV to oral transition therapy for the treatment of complicated urinary tract infections. ERV is being evaluated for the use in the therapeutic treatment of tularemia, plague and anthrax in animal models. Its MIC50/90 values against 33-35 isolates of Francisella tularensis, Yersinia pestis and Bacillus anthracis are 0.12/0.5; 0.06/0.12 and ≤0.016/0.016 μg/ml, respectively. Dosing models were developed to identify once daily IV dosages in cynomolgus monkeys and New Zealand white rabbits equivalent to therapeutic doses of 1.5 or 2.0 mg/kg/day IV ERV. Using fever or increase in circulating protective antigen (anthrax model only) as a trigger-totreat, animals treated for 21 or 28 days with either humanized dose were protected from death due to tularemia or anthrax respectively. Further studies with ERV are warranted to confirm the efficacy seen in the studies and to determine if ERV can be an important empiric therapy for the treatment of respiratory infections by biothreat pathogens.
Joyce A Sutcliffe, PhD, is Senior Vice President for Tetraphase Pharmaceuticals, Inc. Her responsibilities encompass managing discovery biology and preclinical development. She is involved in strategy for clinical development, marketing assessments, budgeting, resource allocation, government contract writing and management of awarded contracts. She has more than 30 years of experience in antibiotic research and development. She is currently the chair of the Antimicrobial Agents and Chemotherapy Division of the American Society for Microbiology. Her expertise is antimicrobial resistance mechanisms: The challenge and the driver for new antibiotics.
image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version