Essential oils of Myrtus communis L. produce a non-sedating anxiolytic effect in mice model of anxiety
3rd International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems
April 08-10, 2013 Hilton Chicago/Northbrook, USA

Eyob Hailu

Accepted Abstracts Posters: Pharmaceut Anal Acta

Abstract:

The present study was undertaken to evaluate the anxiolytic effect of the essential oil of M. communis using different models of anxiety including, elevated plus maze, stair case and open field models. Control groups were given Tween 80 in distilled water. Positive controls received diazepam (0.5 mg/kg, orally), test groups were given the oil suspended in the vehicle at doses of 50, 100, 200 and 400 mg/kg. Both 100 mg/kg and 200 mg/kg of the oil produced a significant increase in percentage of open arm time (P<0.01 and P<0.05 respectively) as compared to the control in elevated plus maze. However, it was only 100 mg/kg of the essential oil that produced a significant increase (P<0.05) in the percentage of open arm entry as compared to the control. In addition, the percentage of time spent in open arm entry by 100 mg/kg of the oil was higher than diazepam (52.82% Vs 50.98%). Evaluation of stair case showed significant reduction of rearing in mice treated with the oil of M. communis at 100 mg/kg (P<0.01) and 200 mg/kg (P<0.05) compared to the control. However, at a dose of 50 mg/kg and 400 mg/kg the oil did not exhibit significant effects on the measured parameters of both elevated plus maze and stair case models. In conclusion, 100 mg/kg of the essential oil of M. communis showed better anxiolytic activity compared to the standard drug. The possible mechanism by which the oil showed the activity could be through GABA-related mechanism.

Biography :

Eyob Hailu had done M.sc. project at the age of 25 under the title ?Essential oils of Myrtus communis L. produce a non-sedating anxiolytic effect in mice model of anxiety? in Experimental Pharmacology Department, Addis Ababa University. He participated and presented his research work in different international conferences that held in Ethiopia {International brain research organization (IBRO) Neuroscience Course, the 10th International Conference of the Society of Neuroscientists of Africa (SONA)} and abroad like {Germany (the XXth World Congress of Psychiatric Genetics, Hamburg) , Morocco (IBRO ALUMNUS School, Fes), UAE ). Currently, he is working as lecturer of Pharmacology and Coordinator of Research and Community Service in Debre Brhane University.