alexa Establishment Of Hepatitis Model In Rat Liver Induced By Injecting Extracted DNA: Histopathological Study
ISSN: 2167-0889

Journal of Liver
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

4th International Conference on Hepatology
April 27-28, 2017 Dubai, UAE

Ahmed S Ibraheem, Mohamed F El-Sayed and Heba A Khalil
Sohag University, Egypt
ScientificTracks Abstracts: J Liver
DOI: 10.4172/2167-0889-C1-011
Chronic inflammatory liver diseases can be induced by viral infections, toxic-metabolic factors and/or autoimmune mechanisms. Inflammation or viral infection results in hepatocyte damage or cell lyses which cause DNA or other cell nuclear materials to be released by hepatocytes to serve as auto-antigens that participate in auto-immune hepatitis. Those released cellular materials will be exposed to the immune system before phagocytosis by Kupffer cells. In this study, injecting rats with extracted DNA combined with CFA resulted in hepatitis cellular symptoms. Plasma globulin was increased and liver function enzymes were higher in plasma and lower in liver tissues compared to CFA and control groups. The inflammation was indicated histologically by the presence of active Kupffer cells, it led to irregularly shaped hepatic lobule, pyknotic cells, vacuolated nucleus and infiltration of liver parenchyma with lymphocytes. Vacuolation of the cells with fatty degeneration and necrotic hepatocytes also, was recorded. It is clear that using cell nuclear materials can induce inflammation that has some hepatitis identity.

Ahmed S Ibraheem has obtained his PhD from Virginia Common Wealth University in 2004 and then moved to Sohag University Egypt. Later, he temporarily started working at Hail University, KSA. The field of specialization for him is Immunology with special focus on Autoimmunity.

Email: [email protected]

image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version