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|Maria Esperanza Avella Vargas, Antonio Jose Lapa, Maria Teresa Riggio Lima-Landman, Mario Francisco Guerrero and Caden Souccar|
|Universidad Nacional de Colombia, Colombia
Universidade Federal de Sao Paulo, Brazil
|Posters & Accepted Abstracts: Biochem Pharmacol (Los Angel)|
|Aim: Calea prunifolia H.B.K. (Cp), known as carrasposa has traditionally been used in Colombia as a medicinal plant. The popular use is recommended as arterial hypotensive, antipruritic, antipyretic and antiseborrheic. In the evaluation of the pharmacological profile, promising effects were found in the gastrointestinal system. Materials & Methods: Calea prunifolia H.B.K. extracts, aqueous (EACp) and ethanolic (EECp), administered orally, were evaluated in vivo in groups of six mice. The experimental models used were: Cold stress induced gastric injury, 75% ethanol induced gastric injury, Pyloro ligation and intestinal transit with activated charcoal. The butanolic fraction (FBu) was evaluated in vitro on rat jejunal contractile activity. Results: In cold stress-induced lesions, the number of ulcers cm-2 (mean+standard deviation) presented a significant difference with CPAS at doses (g/kg of weight) of 0.2 (7.7+2.3) and 0.5 (5.5+4.6) in relation to the control (15.2+6.5) and the ILM at the doses of 0.1 (19.5+1.1), 0.2 (15.33+2.2) and 0.5 (13.2+4.5) with control of (30.4+9.1). The EECp showed a significant difference in the number of ulcers and the ILM in the dose of 1g/kg (6.2+4.9) and (16.9+6.0) respectively. In the ethanolinduced lesions, the number of cm-2 ulcers with CPAS at doses of 0.2 (11.7+9.1) and 0.5 (2.0+1.5) had a significant difference in control (36.5+24.5) and ILM at doses of 0.2 24.1+13.0) and 0.5 (10.4+1.9) to the control (53.6+24.8). In pylorus ligation, no treatment group demonstrated significant difference in gastric pH relative to the negative control (water). In intestinal transit with activated charcoal, a significant difference was found in doses of 0.1; 0.2 and 0.5 g/kg EA and at doses of 0.5 EE. In rat jejunal contractile activity, there is significant difference at 37 degrees. Conclusions: EACp and EECp increase the speed of intestinal transit. Direct gastro protective activity is significant, avoiding the formation and decreasing the severity of gastric ulcers induced by stress and ethanol.|
María Esperanza Avella Vargas is a Professor of Pharmacology and Therapeutics at Military University of Nueva Granada; Leader of the Research Group "Pharmacology, Toxicology and Therapeutics-UMNG" and; responsible for the research seminar "Study of preclinical and clinical research of medicines for its development and application".
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