The present study was undertaken to evaluate the anxiolytic effect of the essential oil of M. communis using different models
of anxiety including, elevated plus maze , stair case and open field models. Control groups were given Tween 80 in distilled
water. Positive controls received diazepam (0.5 mg/kg, orally), test groups were given the oil suspended in the vehicle at doses
of 50, 100, 200 and 400 mg/kg. Both 100 mg/kg and 200 mg/kg of the oil produced a significant increase in percentage of open
arm time (P<0.01 and P<0.05 respectively) as compared to the control in elevated plus maze. However, it was only 100 mg/kg of
the essential oil that produced a significant increase (P<0.05) in the percentage of open arm entry as compared to the control. In
addition, the percentage of time spent in open arm entry by 100 mg/kg of the oil was higher than diazepam (52.82% Vs 50.98%).
Evaluation of stair case showed significant reduction of rearing in mice treated with the oil of M. communis at 100 mg/kg
(P<0.01) and 200 mg/kg (P<0.05) compared to the control. However, at a dose of 50 mg/kg and 400 mg/kg the oil did not exhibit
significant effects on the measured parameters of both elevated plus maze and stair case models. In conclusion, 100 mg/kg of the
essential oil of M. communis showed better anxiolytic activity compared to the standard drug. The possible mechanism by which
the oil showed the activity could be through GABA-related mechanism.
I got my MSC degree in Experimental Pharmacology in Addis Ababa University at the age of 25 and I had worked in different organization for more
than five years as a department head and also as lecturer. I had participated in international brain research organization (IBRO) Neuroscience
Course and also and present my research work on the 10th International Conference of the Society of Neuroscientists of Africa (SONA) and attend
IBRO ALUMNUS School in Fes, Morocco. Currently I am working as lecturer of Pharmacology in Debre Brhane University.
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