alexa Evaluation Of Leukocyte Activity To Construct Immunobiomarker-based Personalized Chemotherapy | 9665
ISSN: 2161-1025

Translational Medicine
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Conference on Translational & Personalized Medicine

Takuya Iwamoto
ScientificTracks Abstracts: Transl Med
DOI: 10.4172/2161-1025.S1.008
Abstract
Leukocytes play important roles in immune response and have been known to influence drug activity. Basophils, one of the leukocytes, mediate many specific kinds of allergic reactions. Upon stimulation with specific allergens that cross-link IgE bound to its high-affinity receptor (FcεR1), basophils rapidly express surface molecules such as CD203c. Flow cytometry- based tests using peripheral blood basophils can presumably represent their in vivo activity for drug allergies. We reported that carboplatin, one of the platinum agents, developed severe anaphylaxis in more than 20% of gynecologic cancer patients after repeated dose of the drug ( Cancer Chemother. Pharm.2011 ). In addition, CD203c positive basophils after in vitro exposure to carboplatin were significantly higher in patients with a history of anaphylaxis (n=11, mean fluorescent intensity: MFI 9.0) compared with those without history (n=19, MFI 0.4). All of the five patients who developed grade 2-4 anaphylaxis during the study period had high CD203c positive basophils on the day before anaphylaxis ( Biol Pharm Bull. 2012 ). We further analyzed the characteristics of activated basophils and revealed that average FcεR1 level located on basophil surface was significantly higher in 5 patients with a history of anaphylaxis than that in 8 patients without anaphylaxis. As described, morphological changes of basophils including receptor expressions should be a useful marker to prevent severe anaphylaxis. These results should provide important sight to understand inter- and intra individual variability in pharmacodynamics.
Biography
Takuya Iwamoto has completed his Ph.D. at the age of 33 years from Mie University. He has also received a title of board certified oncology pharmacy specialist at the age of 36 years. He is an Associate Professor and vice director of hospital pharmacy in Mie University. He has published more than 30 papers in reputed journals. His present areas of major activities and interests are clinical pharmacokinetics and pharmacodynamics with regard to personalized medicine.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7