alexa Evaluation Of The Activity Of Calea Prunifolia H.B.K On Central Nervous System, Analgesic And Antiinflammatory
ISSN: 2167-0501

Biochemistry & Pharmacology: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

9th World Congress on Pharmacology
September 04-06, 2017 | Paris, France

Maria Esperanza Avella Vargas, Antonio José Lapa, Maria Teresa Riggio Lima-Landman, Mario Francisco Guerrero and Caden Souccar
Universidad Nacional de Colombia, Colombia
Universidade Federal de Sao Paulo, Brazil
Posters & Accepted Abstracts: Biochem Pharmacol (Los Angel)
DOI: 10.4172/2167-0501-C1-007
Abstract
Purpose: Calea prunifolia H.B.K. (Cp), known as "carrasposa" has traditionally been used in Colombia as a medicinal plant. The popular use is recommended as arterial hypotensive, antipruritic, antipyretic and antiseborreic. As part of the knowledge of its pharmacological profile, its effects on the central nervous system and as analgesic and anti-inflammatory were studied. Materials and Methods: The extracts, aqueous (EACp), ethanolic (EPAp) and the Butanolic Fraction (FBu) of Calea prunifolia H.B.K., orally administered, were evaluated in vivo in albino Swiss adult mice. To study the effect on the central nervous system, the following tests were performed: Motor coordination test, Rota-Rod test, Evaluation of the Exploratory Activity: Open field test, Evaluation of hypnosis activity, Sleep induced by barbiturate and evaluation of body temperature. The evaluation of antinociceptive activity with the formaldehyde test, Tail-flick test and evaluation of analgesic activity, with the test of abdominal contortions induced by acetic acid. Proof of anti-inflammatory activity in the paw edema test and the carrageenan-induced peritonitis test. Results: In the motor performance test (Rota Rod), the latency for the first drop and the residence time of the animals showed no difference between the treatments and the control, nor were there changes in body temperature. In the evaluation of the exploratory Activity, the EECp showed a significant difference (p <0.05) in relation to the control, with greater number of crossings and the mobility time, both in the periphery and in the center of the field at doses of 0.1, 0.3 and 1 g / kg p.o. and FBu at the dose of 1 g / kg p.o. In the evaluation of the hypnosing activity, with the sleep test induced by pentobarbital (50mg / kg i.p.), a significant increase (p <0.05) in the latency time was observed in all doses of FBu (0.1, 0.3 and 1 g / kg p.o.) and the highest dose of the EECp 1g / kg. A significant analgesic effect (p <0.05) like indomethacin was observed in the 1.5% formaldehyde test (30 μL / paw, s.p.), with the EACp and EECp at the highest concentration (1 g / Kg p.o.) relative to the control. In the Tail-flick test, there is a protective effect at 30 min of administration of the EACp at the dose of 0.5 mg / kg and a significant antinociceptive effect (p <0.01) in the test of abdominal contortions induced by 0.8% acetic acid in mice, with administration of EACp (0.1, 0.2 and 0.5 g / kg p.o.). No anti-inflammatory effect was demonstrated in the tests used. Conclusion: In these screening tests, Cp presents analgesic effects that must be evaluated and confirmed in the determination of its mechanisms of action, as a potential pharmacological resource for pain management.
Biography

María Esperanza Avella V. She is professor of pharmacology and therapeutics in the Medical and Surgical Clinics Area of the Faculty of Medicine of the Military University of Nueva Granada. Leader of the Research Group "Pharmacology, Toxicology and Therapeutics-UMNG" and responsible for the Research Seminar "Study of preclinical and clinical research of medicines for its development and application". As PhD student, he belongs to the Research Group: "Search for Bioactive Principles in Colombian Medicinal Plants" of the Department of Pharmacy of the Faculty of Sciences of the National University of Colombia in the city of Bogotá.

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version