the use of biological glues and their application between the two dissection
layers and into the anastomosis region is a common integral part of surgical management of
thoracic aortic dissection.
e aim of the experimental study was to assess and evaluate histopathological changes
of vascular wall following deposition of the following three types of glue ? GRF, Tissucol,
Bioglue, based on qualitative and quantitative parameters. Th
e secondary aim of the study was
to assess dynamics of these changes depending on the glue eff
ect duration and to formulate
expected behaviour of the vascular wall during the time beyond the experimental period.
e dissection model was performed with pigs of the same gender and age,
assigned to four groups. Diff
erent glues were used to close artifi
cial infrarenal aortic dissection
in Group 1-3, while direct suturing and no glue was used to close false lumini in Group 4.
Samples of the dissected aorta were then collected at Month 1, 6 and 12 and then histologically
Upon assessment of the whole group of qualitative and quantitative parameters,
the most signifi
cant changes in the smooth muscle histological picture were observed with the
use GRF glue. Th
e smooth muscle changes following the Bioglue application and, in particular,
Tissucol glue application, are similar to changes observed in Group 4, where no glue was used.
Based on the results, the authors present a hypothesis that, in a long-time
horizont, vascular wall destructions, eventually redisections, are likely to occur more frequently
in patients, in whom GRF glue is used
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