alexa Evaluation Of The Role Of Immunohistochemical Expression Of EGFR (ERB B1) And Her4 (ERB B4) In Urinary Bladder Urothelial Carcinoma
ISSN: 2161-0959

Journal of Nephrology & Therapeutics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

11th International Conference on Nephrology & Urology
March 22-23, 2017 Rome, Italy

Nafissa El Badawy, Nermeen Youssef, Amira Ismail, Faten Ragheb and Sara Hakim
Ain Shams University, Egypt
ScientificTracks Abstracts: J Nephrol Ther
DOI: 10.4172/2161-0959.C1.036
Background: EGFR (ERB B1) and HER4 (ERB B4) are members of the ERB B family of receptors. Overexpression of ERB B receptors has both prognostic and therapeutic significance in various malignancies including breast, colorectal, prostate and ovarian cancer. However, the prognostic significance of their expression in urothelial carcinoma remains controversial. The aim of this work is to evaluate the prognostic value of EGFR and HER4 in urothelial carcinoma of urinary bladder. Material & Methods: Fifty (50) archived cases of urothelial bladder carcinoma, cases of which had synchronous metastatic lesions in lymph nodes, as well as 13 samples of normal ureters were studied by immunostaining for EGFR and HER4. Results: Membranous EGFR, cytoplasmic HER4 and nuclear HER4 expression were detected in 74%, 46% and 32% of urothelial carcinoma, respectively; and 15.4%, 100% and 0% of normal ureteric samples, respectively with statistically significant differences between the two groups regarding the expression of both markers (p<0.05). Membranous EGFR as well as nuclear HER4 expression showed statistically significant association with non-papillary tumors, high histologic grade and advanced tumor stage (p<0.05). There was a highly statistically significant inverse relationship between cytoplasmic and nuclear HER4 expression (p=0.0001) as well as between EGFR and cytoplasmic HER4 expression (p=0.001). There was no statistically significant association between EGFR and nuclear HER4 expression (p=0.051). Conclusion: EGFR and nuclear HER4 expressions were associated with parameters of poor prognosis in urothelial carcinoma while cytoplasmic HER4 expression was related to good prognostic indicators. Both markers may help in selecting high-risk patients for more aggressive therapy.

Nafissa El Badawy is a Professor of Pathology at Ain Shams University, Cairo, Egypt. She completed her PhD. She had Post-graduate Fellowship at Emory University, Atlanta, Georgia, USA. She also had a Fellowship in Dusseldorf, Germany. She is the President of Egyptian Fellowship of Pathology Program in Egypt. She is Editor in the African Journal of Urology and Journal of Egyptian Society of Pathology.

Email: [email protected]

image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version