alexa Evolution Of A System For Surgical Treatment Of Adenocarcinomas | 69466
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

JOINT EVENT:19th Euro Congress on Cancer Science and Therapy & 25th Cancer Nursing & Nurse Practitioners Conference

Charles L Hitchcock and Edward W Martin
The Ohio State University, USA
ScientificTracks Abstracts: J Cancer Sci Ther
DOI: 10.4172/1948-5956-C1-105
Abstract
Current imaging and exploration of the surgical field using inspection and palpation provides the surgeon with limited information for clinical decision making. Using colorectal adenocarcinoma as a model, we developed a “system” that incorporates currently available technologies to increase the precision of tumor imaging before and during surgery. The system has three parts: 1) a tumorrelated marker, 2) a labeled molecular probe, and 3) instrumentation for imaging and/or detection of the labeled tumor. The glycoprotein TAG-72 is expressed in more than 80% of adenocarcinomas of the: colon and rectum, pancreas, lung, prostate, endometrium, and ovary. We utilized three different generations of 125I-labeled murine IgG antibodies to TAG-72. Our earlier studies used a hand-held gamma probe for the detection and excision of TAG-72 positive tissues. Follow-up studies clearly demonstrated that, independent of the pathologic stage, patient survival was significantly better if all of the TAG-positive tissue was removed. In the last 25 tears the “system” has evolved to the use of low energy labeled, small, molecular probes that allow for combined intraoperative imaging and detection. We bioengineered humanized, single chain, fragments and its “mers”, to TAG-72 that minimize murine antibodies associated problems. 123I-labeling of these small molecules provides an optimal signal-to-noise ratio. The “System” now allows for preoperative SPECT/CT imaging to determine actual disease extent prior to surgery and for using a portable gamma camera for realtime intraoperative imaging while retaining hand-held-gamma probe detection of TAG-72 positive tissue. Proof-of-concept studies clearly demonstrate that the surgeon can “get it all”.
Biography

Charles L Hitchcock is an Emeritus Faculty member of the Department of Pathology at The Ohio State University in Columbus, Ohio USA. For the last 35 years, he has been a member of a multidisciplinary team of physicians, engineers, chemists, and biomedical scientists whose goal is to provide physicians with the resources to optimize the treatment of patients with solid tumors. Their efforts have resulted in over 500 publications and abstracts, multiple research grants, patents, and several biotech companies.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7