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In search for drugs that can target cancer cell microenvironment in as much as being able to halt malignant cellular
transformation, the natural dietary phytochemical curcumin was currently assessed in DMH-induced colorectal cancer
rat model. The study enrolled 50 animals divided into a control group (n=10) and DMH-induced colorectal cancer control
group (n=20) (20 mg/kg body weight for 28 weeks) versus curcumin treated group (n=20) (160 mg/kg suspension daily oral
for further 8 weeks). Treatment by curcumin succeeded to significantly decrease the percent of ACF and tended to normalize
back the histological changes retrieved in adenomatous and stromal cells induced by DMH. The drug also significantly elevated
GSH and significantly reduced most of the accompanying biochemical elevations (namely MDA, TNF-α, TGF-β & COX2)
observed in colonic carcinomatous tissue, induced by DMH, thus succeeding to revert that of MDA, COX2 & TGF-β back to
near normal as justified by being non-significantly altered as compared to normal controls. The only exception was PAF that
was insignificantly altered by the drug. When taken together, it could be concluded that curcumin possess the potentiality to
halt some of the orchestrated cross-talk between cancerous transformation and its micro environmental niche that contributes
to cancer initiation, progression and metastasis in this experimental cancer colon model. Envisioning these merits to a drug
with already known safety preferentiality, awaits final results of current ongoing clinical trials before curcumin can be added to
the new therapeutic armamentarium of anticancer therapy.
Azza Hafiez El-Medany has completed her PhD and Postdoctoral studies from Alexandria University, College of Medicine, Egypt. She is the Professor of Pharmacology & vice Head of the Department of Pharmacology, College of Medicine, KSU. She has published more than 40 papers in the areas of GIT, CVS, natural products & toxicological researches in reputed journals and serving as a member of number of professional bodies. She is the recipient of special awards in scientific research & teaching.