Breast cancer (BC) is one of the widespread diseases of the women. Every year worldwide about 700 thousand new cases of
BC are registered. In spite of the high rates of early diagnostic abilities, 30-50 % of aff
ected women refer to medical care in
third stage of disease that is when they have locally advanced (LA) BC. In this connection morphologic verifi
cation of diagnosis
has not only diagnostic but prognostic value too.
Objectives of our study were to evaluate the diagnostic capabilities of core-needle biopsy in patients with LA BC. Aft
diagnostic investigations (USS and mammography of mammary glands) of 41 women at the age of 30-75 years core-needle
biopsy of aff
ected mammary gland with further histological verifi
cation, evaluation of malignancy rate and receptor status of
tumour were performed.
In research group 39 women had infi
ltrating BC (II ? III degree of malignancy), 2 had intraductal BC with beginning infi
In 29 women immunologic, histological and chemical investigation of tumour was performed: luminal type was found in 15
patients, in 13 patients result was negative and 1 patient had HER2/ neu type.
e analysis of received data shows that core-needle biopsy can be used as primary diagnostic procedure in cases of LA BC. As
a result clinician obtains a full value information about histological structure of tumour aft
er low invasive procedure, which is
good endured by patients.
Khakimov Golib Abdullayevich: MD, Professor. Head of Department of Oncology in Tashkent Pediatric Medical Institute. Has publis
hed more than
100 papers in reputed journals.
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