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Chagas? disease, caused by Trypanosomacruzi, is a major health problem in LatinAmerica. Immune response to T cruzi
infection is highly complex and involves many components, regulators and effectors.This parasite is able to survive and
replicate in its host because it is adapted to resist host defences.A model for vaccinating mice with Trypanosomarangeli, a
parasite closely related to T. cruzi, but non-pathogenic to humans, has been designed in our laboratory, showing protection
against T. cruzi infection.The aim of this work was to analyse some mechanisms of the early innate immune response in this
In the first hours of infection, vaccinated mice showed a strong innate immune response. The adherent cells revealed
important phagocytic activity, and some soluble mediators showed modifications: Respiratory Burst: significantly increase;
NO: adequate levels; Arginasa: significantly increase.Further more, they showed an increase of macrophages, NK, granulocytes,
and regulation of IL6, IFN?, TNF? and IL10, with an increase of IL12, with respect to only infected mice.
Conclusion: in this model some cellular populations and mediators soluble, involved in the innate immune response,
plays an important role in vaccinated mice for the early elimination of the parasites. These results also suggest that in mice
vaccinated with T. rangeliinnate response could develop some kind of immunological memory, equivalent to adaptative
immune response, recognizing shared antigens between T. rangeli and T.cruzi. These results could contribute to the knowledge
of new mechanisms which would have an important role in the immunono prevention of Chagas disease.
Beatriz Basso obtained her PhD at School of Biochemistry,National Cordoba University, Argentina. She is Professor of Medicine School at the same University and Director
of the Parasitology Laboratory, National Service of Chagas? disease.She was Visiting Researcher in Universities of USA and Belgium, Director of graduate students and
PhD. She has published more than 100 papers in national and international journals, over 200 presentationsat congress, with several awards. She is evaluator of national
and international research project, editorial board member and reviewer of international researchjournal, among other academic and research activities.
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