Journal of Clinical & Experimental Pharmacology

Exploring ethnopharmacological potential of Australian native old man saltbush and wattle seed with untargeted metabolic profiling and structural elucidation with mass spectrometry

8^th World Congress on Pharmacology and Toxicology

July 24-25, 2017 Melbourne, Australia

Rashida Bashir, Andrew Jones, Andrew Shalliker, Enzo Palombo and Peter Mahon

University of Western Sydney, Australia
Swinburne University of Technology, Australia

Posters & Accepted Abstracts: Clin Exp Pharmacol

Abstract:

Currently, there are 119 drugs of known structure that are still extracted from higher plants and used globally in allopathic medicine. Ethnomedical and traditional medicinal use of Australian aboriginal plants can provide information that is useful to pre-screen them for experimental pharmacological studies. Australian aboriginal people use old man saltbush topically as a medicine for cuts and stings and wattle seeds as a mild sedative for rheumatism or indigestion. This study intended to attract the attention of ethnopharmacologists to focus on the unexplored potential of both edible plants. Recent advances in bioanalytical technologies have emerged as a critical tool in the process of drug discovery and development. Nontargeted metabolomics with Reaction Flow Chromatography-Post Column detection-Ferric reducing Antioxidant potential assay (RF-PCD-FRAP) and LC-ESI-MS analysis implies that Australian native saltbush and wattle seed are rich sources of antioxidants. Underivatized and derivatized reactions were simultaneously monitored to attain information of complex samples. Analytes were identified by MS and MS2 with the ESI mass spectra under the same conditions in both positive and negative ionization modes. Isorhamnetin, Rhamnetin, Asarone, Nookatone, Brevifolin and Apocynin Quinic acid, Citric acid, Gallic acid, Quinovic acid, β-D-glucoside, D-Pantothenic acid and 4�?�-0-beta glucose 4-p-Coumaroylquinic acid were the main bioactives found within samples, which may be responsible for their well-known therapeutic roles of these plants. Both samples have exhibited superior antioxidant capacity and comprise predominantly of flavonols, anthocyanin, phenolic acids and contains bioactives with known therapeutic potential in cardiovascular, neurodegenerative and other chronic diseases that play a major role in the prevention/delay of diseases.

Biography :

Rashida Bashir has previously completed Masters of Biotechnology and Bachelor of Pharmaceutical Sciences. She has recently submitted her PhD thesis in the area of Natural Products and Bioanalytical Chemistry under the supervision of Dr. Peter Mahon and Professor Enzo Palombo.

Email: rbashir@swin.edu.au