Journal of Clinical & Experimental Pharmacology

Exploring for bioactive secondary metabolites from the Chinese medicinal mangroves

2^nd International Conference and Exhibition on Pharmacology and Ethnopharmacology

May 02-04, 2016 Chicago, USA

Yue Wei Guo

Shanghai Institute of Materia Medica- Chinese Academy of Sciences, China

Keynote: Clin Exp Pharmacol

Abstract:

Mangroves comprise a large number of various salt-tolerant plants growing in tropical and subtropical intertidal estuarine zones. Historically, many mangrove plants were used to treat various diseases in traditional Chinese medicine. Currently, the secondary metabolites found in mangroves represent an extremely rich source of novel chemical diversity for academic drug discovery and chemical biology programs. It is particularly true that the mangroves from Southern Coast of China are very prolific producers of bioactive natural products. Our group at SIMM has long been engaged in searching for novel secondary metabolites with pharmacological potential from Chinese mangrove medicinal plants. In collaboration with biologists and pharmacologists at SIMM, many mangroves used as fork medicine were chemically investigated and numerous novel isolates obtained were pharmacologically screened for activity in a variety of cell-based and pure enzyme assays designed to identify promising lead compounds for the development of drugs in the therapy of human diseases. This presentation will discuss examples of bioactive metabolites (structures and activities) from our recent discovery efforts.

Biography :

Yue Wei Guo has completed his PhD from Naples University and Postdoctoral studies from Istituto di Chimica Biomolecolare-CNR, Italy and Hokkaido University, Japan. He is the Professor of SIMM-CAS, a premier drug R/D organization. He has published more than 350 papers in reputed journals and has been serving as an Editorial Board Member of repute.

Email: ywguo@simm.ac.cn