alexa Exploring The Involvement Of The Regulatory Genome In Personalised Medicine, Drug Response And Disease Stratification
ISSN: 2161-1025

Translational Medicine
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Conference on Translational & Personalized Medicine
August 05-07, 2013 Holiday Inn Chicago-North Shore, IL, USA

Alasdair Mackenzie
ScientificTracks Abstracts: Transl Med
DOI: 10.4172/2161-1025.S1.008
Abstract
Human health is critically reliant, not only on the expression of normal proteins, but the appropriate expression of these proteins within the correct cells, in the correct amount and in response to the correct stimuli. However, very little is known about the components within the human genome that modulate normal gene expression or how they are compromised by polymorphic variation (SNPs) to increase disease susceptibility or alter drug response within the human population. Considering that the majority (87%) of disease associated SNPs identified by genome wide association studies are found outside of coding sequences, this lack of knowledge is hampering our ability to understand the genomic basis of disease and drug response stratification. Non- coding sequences called cis-regulatory sequences (CRSs) direct cell-specific and inducible gene expression in response to specific signal transduction networks. It is becoming apparent that many cases of disease susceptibility and drug response stratification are due to polymorphisms that alter CRS responses in a context-dependent manner. My seminar will describe the successful use of bioinformatics, cell based and transgenic methods used in our laboratory for identifying CRSs and analyzing the effects of disease associated allelic variation on their cell specificity and response to drug treatments. The technologies described build on the successes of ENCODE by exploring the effects of polymorphisms on CRS context dependency and drug response. This understanding is essential to uncovering the genomic basis of disease susceptibility and only by better understanding the effects of SNPs on the regulatory genome can we deliver on the promises of personalized medicine.
Biography
MacKenzie (AM) graduated with his Ph.D. from the University of Manchester in 1992 before carrying out 10 year of post-doctoral study at the University of Edinburgh. In 2001 AM set up his research lab at the University of Aberdeen and was promoted to Reader in 2008. He has published in many high impact journals such as PNAS Mol. Psychiatry, J. Clin. Investigation, Arthritis and Rheumatism, Am. J. Psychiatry Neuropsychopharmocology and most recently in Biological Psychiatry and Trends in Molecular Medicine.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version