Expression discrimination of STAT3, NF-κB3 in the Uygur and Han asthma patients in Xinjiang Urumqi

JOINT EVENT ON 15^th International PHARMACEUTICAL MICROBIOLOGY AND BIOTECHNOLOGY CONFERENCE & 10^th Annual MEDICAL MICROBIOLOGY SUMMIT & EXPO

June 21-23, 2017 London, UK

Yao Li-Min, Jiang Xiao-fang, Delixiati Yimiti and Gao Li

Xinjiang Medical University, China

Posters & Accepted Abstracts: J Med Microb Diagn

Abstract :

Background: The STAT3 and NF-�ºB3 transcription factor is critical for cytokine signaling and the acute phase response, but its role in allergic asthma is largely undefined. Aim: Aim of this study is to investigate the expression levels of STAT3 and NF-�ºB3 in Xinjiang Uygur and Han population of asthma and healthy individuals. Method: Peripheral Blood Mononuclear Cells (PBMCs) were isolated from Xinjiang Uygur asthma (n=25), Han population asthma (n=115) and healthy individuals (n=121). The expressions of STAT3mRNA and NF-�ºB3 (P65) mRNA were quantified through the RT-PCR. Results: The distribution of expression of STAT3mRNA and NF-�ºB3mRNA was significantly different between asthma group and healthy controls. The distribution of expression of STAT3mRNA was significantly different between Xinjiang Uygur asthma group and Han population asthma group. There was no difference of distribution of expression of NF-�ºB3mRNA between Xinjiang Uygur asthma group and Han population asthma group. Conclusions: It is indicated that the STAT3 and NF-�ºB3 might be involved in the etiology of asthma.