Journal of Cell Science & Therapy
Open Access
ISSN: 2157-7013
+44 1300 500008
ISSN: 2157-7013
+44 1300 500008
Zahra Madjd, Mitra Mehrazma, Elham Kalantari and Mahshid Panahi
Scientific Tracks Abstracts: J Cell Sci Ther
Background: Based on cancer stem cell (CSCs) hypothesis, a small population of cells with unique self-renewal properties and malignant potential exists in solid tumors. Recent evidences indicate that transmembrane protein CD133 and adhesion molecule CD44 , can be used as markers of CSCs. Methods: Immunohistochemistry was performed to detect the expression of CD133 and CD44 in a series of pediatric solid tumours including 32 wilm?s tumour, 18 neuroblastoma (NB ), 30 Hodgkin and non-Hodgkin lymphoma ,4 Rabdomyosarcoma, 4 Hepatoblastoma,, 9 Teratoma, and 4 yolk sac tumour which have been previously included in tissue microarray. Th e association between expression of these markers and tumours characteristics were then analyzed. Results: Th e cytoplasmic expression of CD133 in wilm?s tumour, neuroblastoma and lymphoma were 44%, 39% and 24% respectively. Expression of CD133 in neuroblastoma patients with unfavorable histology was signifi cantly higher than that in patients with favorable histology (p-value =0.011). Moreover, the positive rate of CD133 in younger children (< 51 months) was signifi cantly higher than children over this age (p-value=0.025). CD44 was expressed in cell membrane of 43% of pediatric tumours and its expression was signifi cantly associated with tumor size (p-value Conclusions: CD133 can be an important indicator for prognosis of neuroblastoma, therefore this molecule may play a role as a potential clinical marker in younger children suff ering from neuroblastoma
Dr Zahra Madjd has completed her MD in Tehran, Iran and conducted her PhD and postdoctoral studies from Department of Clinical Oncology, University of Nottingham, UK. She is currently assistant professor of Immunopathology at Departments of Pathology and Molecular Medicine, also research deputy of Oncopathology Research Centre, Tehran University of Medical Sciences. She has published more than 28 papers in prestigious journals and serving as co-editor of ?Iranian J Cancer Prevention?