alexa Expression Of Telomerase Reverse Transcriptase In Soft Tissue Tumor In Conjunction With Hypoxia-inducible Factor-1 α, Tumor Angiogenesis And Related Molecules P53, P21, Rb, Ki67 And Mdm2
ISSN: 2161-1076

Surgery: Current Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

13th International Conference on Surgical Pathology & Practice
March 27-28, 2017 Madrid, Spain

Hanan Mohammed Abd Elmoneim, Rehab Kamal Mohammed, Manal Ismail Abd Elghany, wafa Aref and Timothy Helliwell
Minia University, Egypt
Umm Al-Qura University, KSA
University of Liverpool, UK
Posters & Accepted Abstracts: Surgery Curr Res
DOI: 10.4172/2161-1076.C1.030
Background: Telomerase enzyme is a ribonucleo-protein complex with reverse transcriptase activity. The catalytic subunit (Telomerase reverse transcriptase) TERT correlates with poor clinical outcome in various tumors. Tumors expressing this enzyme may be more aggressive and telomerase activity may be a useful prognostic marker. For soft tissue tumor little is known about telomerase activity and most of reports focus on telomerase activity in liposracomas. Aim: This study was conducted to investigate the relationship between expression of the catalytic subunit of telomerase (h-TERT), cell proliferation and hypoxia in a range of soft tissue neoplasms. Material & methods: A tissue microarray was constructed from 101 cases and whole sections were cut from 21 cases of soft tissue neoplasm. Immunocytochemistry for h-TERT, HIF-1 α, p53, p21, Rb, CD31, Ki67 and MDM2 was done. Western blotting for hTERT protein of 12 sarcomas was performed to validate h-TERT expression. Results: h-TERT was expressed in 16% of benign and 65% of malignant neoplasms (p<0.005) with higher expression in leiomyosarcomas, synovial sarcomas, undifferentiated sarcomas and myxofibrosarcomas and lower expression in liposarcomas. h-TERT expression was significantly associated with grade (p=0.000), stage (p=0.000) and size of the tumor (p=0.02). Higher expression of HIF-1 a and Ki67, and loss of Rb expression were associated with high grade sarcomas (p<0.004). Expression of p53 and MDM2, p21 and tumor vascularity were not associated with grade. High expression of HIF-1 α and Rb were significantly associated with the stage (p=0.002, 0.03). Conclusion: hTERT is expressed in a wide range of high grade sarcomas. The positive correlations between proliferation, hypoxia and vascularity support the view that mesenchymal cells are adapted to proliferate in a hypoxic environment. Increased expression of hTERT may be part of this adaptive response.


image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version