Fabrication and characterization of FP metered dose inhaler for pulmonary drug delivery

5^th International Conference on Medicinal Chemistry & Computer Aided Drug Designing and Drug Delivery

December 05-07, 2016 Phoenix, USA

Priya Patel, Tejal Soni, Vaishali Thakkar and Tejal Gandhi

Saurashtra University, India

Posters & Accepted Abstracts: Med chem

Abstract :

The purpose of present research work was to fabricate FP metered dose inhaler and study the effect of spray drying parameter on production yield and particle size. Spray-dried powders can be used to deliver particles to the lungs via a MDI. Nanoparticles were generated using polymer chitosan, mannitol along with L-leucine. The effects of various experimental parameters were optimized by means of experimental box-behnken design. Production yield, encapsulation efficiency and dissolution study along with characterization by scanning electron microscopy, X-ray diffraction, DSC, IR. Particle size and zeta potential were evaluated by using zetatrac particle size analyzer, cascade impactor using investigated aerodynamic properties. Histopathology of lung were also examined for the normal group, cigarette smoke exposed group, treatment group and was compared with marketed group investigated the characteristic of developed MDI. Experimental design it was evaluated that inlet temperature and polymer concentration influence on the production yield. Feed flow rate impact on particle size. Results showed that spray drying technique yield 985 to 4060nm indicate nano-size range. Entrapment efficiency was found between 89.35% and 98.36%. Zeta potential shows good stability index of nanoparticle formulation. Prepared nanoparticles emit 36 to 45% investigated by cascade impactor indicate deep targeting of FP to alveoli. Diffusion kinetic was found to be predominant as mechanism follow higuchi. Histopathology revealed that MDI protects the lungs against the chronic inflammation and airspace enlargement reducing. By Developed MDI shows good spray pattern of MDI shows uniform and spherical spot with better uniformity 95.64�±0.12% in term of content per puff and also found non inflammable. Spray drying technique yield optimum size for deposition beyond the narrow airway into the alveoli. That is suitable for respiratory deposition. This delivery platform opens up a wide range of treatment applications of pulmonary and systemic diseases using targeted delivery strategies via nano-particle

Biography :

Email: patelpriyav@gmail.com