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The aim of current study is to investigate the influence of different encapsulation parameters on entrapment of a model
lipophilic molecule, rhodamine into self-assembled layer-by-layer (LbL) microcapsules.
Charged polymers including polyallylamine hydrochloride (PAH) and poly (sodium-4-styrene sulfonic acid) (PSS) were
used to prepare microcapsules on a sacrificial calcium carbonate template. Microcapsules with six bilayers of charged polymers
were characterized using scanning electron microscope (SEM), differential scanning calorimeter (DSC) and Fourier-transform
infrared spectroscopy (FT-IR). Influence of incubation time, drug concentration, pH and ionic strength on entrapment of
rhodamine into microcapsules was studied.
Microscopy showed that calcium carbonate microspheres and LbL microcapsules were spherical in shape, with average
particle size of 1.5?0.7μm and 2.3?0.2μm respectively. FT-IR studies showed proportional increase in area of characteristic peaks
of PAH and PSS in prepared microcapsules. DSC thermograms showed interaction of polymers in microcapsules and rhodamine
entrapment with shift in Tg of polymers and Tm of rhodamine. One hour incubation of microcapsules with rhodamine solution
showed encapsulation efficiency of 60.27?1.65%. Rhodamine showed increased encapsulation in microcapsules with increase in
concentration from 0.25?1mg/mL and pH from 2 to 8 with maximum of 42.80 ? 5.27% at pH 6.75. Increase in salt concentration
from 0 ? 0.5M show increase in encapsulation efficiency from 42.80 ? 5.27% to 61.00 ? 4.08%.
In-vitro release studies showed controlled release of rhodamine from microcapsules with 64% released over a period of 48hr
in comparison to 98% release at 5hr for rhodamine solution.
Our studies showed that self-assembled LbL microcapsules can be developed as carriers for controlled delivery of charged
Rahul Sharma is currently pursuing M. pharm in pharmaceutics from Department of Pharmacy, BITS Pilani Hyderabad campus. He has been
working on layer by layer technology for the fabrication and characterization of polyelectrolyte films and microcapsules since last 10 months under
the guidance of Dr. V.V. Vamsi Krishna, Head of department, Department of Pharmacy, BITS Pilani Hyderabad campus.
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