alexa Fagonia Cretica L.: Antioxidant Potential, Protective Effects On H2O2-induced DNA Damage And Identification Of Polyphenols By RP-HPLC Analysis
ISSN: 2329-6836

Natural Products Chemistry & Research
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2nd International Conference and Exhibition on Pharmacognosy, Phytochemistry & Natural Products
August 25-27, 2014 DoubleTree by Hilton Beijing, China

Samreen Saleem, Laila Jafri, Jasia Bokhari, Nazif Ullah and Bushra Mirza
Accepted Abstracts: Nat Prod Chem Res
DOI: 10.4172/2329-6836.S1.005
Abstract
Fagonia cretica L. is a popular folk medicine and it is used with honey in rural areas of Pakistan for its thirst quenching and blood purifying properties. The present study was designed to determine antioxidant potential and polyphenolic compounds of F. cretica. Total phenolic and flavonoid contents of F. cretica were estimated and protective effects of plant extracts on H2O2-induced DNA damage was determined. Ethyl acetate extract of F. cretica (FCE) contained highest amount of phenolics and flavonoids and its antioxidant and protective activities in all tested antioxidant systems were higher than the other extracts. All extracts of F. cretica showed significant protection in H2O2-induced DNA damage assay. The RP-HPLC analyses provided first ever report regarding the presence of important natural antioxidant compounds such as gallic acid, chlorogenic acid, rutin, quercitrin and kaempferol in FCE. These results indicate that F. cretica extracts possess potent antioxidant activities tested in this study and could be used as a potential therapeutic agent in the treatment of diseases involving oxidative stresses.
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