Fentanyl administration frequently used during the induction of general anesthesia and can reduce hyper dynamic
reaction of trachea. Fentanyl-induced cough is not an uncommon condition during the induction of general anesthesia.
Various attempts have been made to reduce the incidence of fentanyl-induced cough during anesthesia induction. Propofol may
also induce bronchodilation. We hypothesized that an appropriate dose of propofol might suppress fentanyl-induced cough.
So, we designed a randomized controlled study to observe the effects of propofol on fentanyl-induced cough during anesthesia
A total of 113 patients aged 25 to 60 years, of American Society of Anesthesiologists physical status I/II, scheduled to
undergo elective orthopedic surgery with general anesthesia were enrolled in the present study. Patients were randomly allocated
to two groups. Group 1 patients were given fentanyl at a dosage of 4 μg/kg; Group 2 patients received 4 μg/kg fentanyl and 20 mg
propofol. Two groups were evaluating in 0,5,10 minute after injection. For statistical analysis, we used SPSS Statistics version 17
Patients Mean age was 35?10.96, weight 67.99?10.92, and height 161.33?31.84. The incidence of fentanyl induced cough
was 29 (51.8%) in placebo group compared with 10 (17.5%) in fentanyl group There was significant difference in the incidence
and severity of cough between groups 1 and 2 (p<0.000).
A priming dose of more than 20 mg of propofol given 1 minute before fentanyl is effective to suppress fentanyl-
fentanyl, cough, propofol
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