Fijian Medicinal Plants Used In The Treatment Of Alzheimers Disease And Related Illness | 96088
Alternative & Integrative Medicine
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Background: Traditional and alternative medicine is the indigenous healthcare method that is still widely in the developing
countries. Traditional medicine has been part of the Fijian culture due to its safety and effectiveness to illnesses. However,
this knowledge is restricted to only the traditional village healers. In a survey carried out recently in Fiji, thirteen traditional
medicinal plants were selected, those that were used by Itaukei village healers to cure headache, depression and related sickness.
Since the traditional method for medicine preparation is extraction in water, the plant samples used in the study were extracted
with water and ethanol. The crude extracts were then analysed for acetylcholinesterase inhibition (AChEI) using Ellman???s assay.
Method: Thirteen plant species belonging to Melastomataceae, Asteraceae, Apiaceae, Rutaceae, Goodeniaceae, Loganiaceae,
Araliaceae, Solanaceae, Polygonaceae, Zingiberaceae and Anacardiaceae families were tested at 0.2 mg/ml, 0.4 mg/ml, 0.6 mg/
ml, 0.8 mg/ml, 1.0 mg/ml, 1.5 mg/ml and 2.0 mg/ml concentrations.
Result & Discussion: The most active plants showed AChEI activity between IC50=4.57 mg/ml to IC50=9.24 mg/ml indicating
the effectiveness of the compounds present in the extracts against the acetylcholinesterase, the enzyme that plays a key role in
normal cognition and memory.
Conclusion: The plant extracts used in this study were crude extracts, thus the concentration of the active phytochemicals
present may be of avery low concentration. These thirteen plants could prove leads to safer and better candidates for the future
selection of acetylcholinesterase inhibitors and potenially in treatment of Alzheimer???s disease and related illness.
Romila Gopalan has completed his PhD in 2012 from Monash University. She is currently a Senior Lecturer at The University of the South Pacific. Her research is mainly in the areas of functional foods, medicinal chemistry and natural products chemistry. She has published in many reputed journals and also involved in Research Skill Development and Science Edication at The University of the South Pacific.