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Formulation And Evaluation Of Anti-migraine Controlled Release Microspheres Of Sumatriptan Succinate | 7523
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
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Formulation and evaluation of anti-migraine controlled release microspheres of sumatriptan succinate

2nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

Ashish Bisen, Ruchi Maurya and Juhi Tiwari

Accepted Abstracts: Pharmaceut Reg Affairs

DOI: 10.4172/2167-7689.S1.008

Abstract
Sumatriptan is the most commonly prescribed drug for migraine attacks. But the major problem with oral route is very low bioavailability (15%) due to pre-systemic metabolism and incomplete absorption. Hence sumatriptan is selected as model drug for colon targeted drug delivery system. The colon route has some advantage due to its large surface area, rich blood supply, avoidance of the first pass effect. The purpose for the present investigation is to formulate and evaluate microspheres for colon drug delivery system of sumatriptan succinate using solvent evaporation method. Microspheres are prepared using various natural biodegradable polymers xanthum gum and guar gum. Natural polymers particularly in the form of microspheres, have an important role in better understanding of the kinetics of drug release, more effective ways to control burst phenomena, greater understanding of drug-polymer interactions and their effect on the shelf life stability. The effect of different ratios of polymer in the preparation was identified. The drug release from the prepared system was carried out and was compared with Sumatriptan succinate tablets. Further the microspheres prepared were also tested for entrapment efficiency, swelling index, vesicle size and in-vitro analysis.
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