alexa Formulation And Evaluation Of Anti-suicidal Nasal Spray Of Thyrotropin Releasing Hormone | 26132
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

4th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

Patel P A and Patel V R
Accepted Abstracts: Pharmaceut Anal Acta
DOI: 10.4172/2153-2435.S1.022
Abstract
A multi dose nasal spray drug delivery system has been described in this study. Thyrotropin releasing hormone is an antisuicidal, act by attaching to thyrotropin receptors in the brain and inhibit the suicidal behavior and/or depression. Dose of TRH is 200 μg and can be given once in a day. In the present study, an attempt has been made to prepare nasal spray of TRH by optimizing its pH, viscosity, osmolality and formulation parameters for use in crisis management. Results of preformulation studies of TRH indicate that it has fair solubility and molecular weight to be formulated under nasal drug delivery. To improve the muco-adhesive property, muco-adhesive agent (like sodium carboxymethyl cellulose) was used in the formulation of nasal spray. Results of DSC and FT-IR study have shown that there was no interaction between drug and excipients. F001 to F017 batches were formulated by using different concentration of sodium carboxymethyl cellulose, disodium hydrogen phosphate and sodium dihydrogen phosphate supported by response surface methodology using Box-Behnken factorial design. The prepared solutions were examined for various evaluation parameters like pH, viscosity, osmolality, pump delivery, spray pattern, assay, shot weight, spray content uniformity and plume geometry. The optimization of formulation was done by using box-behnken design. The optimized formulations were subjected to stability studies as per ICH guidelines at 40?C temperature and 75% relative humidity.
Biography
Patel P A has completed his Ph.D. at the age of 32 years from Hemchandracharya North Gujarat University, India. He is an Associate Professor at Shree Swaminarayan Sanskar Pharmacy College, Gujarat, India. He has published more than 35 papers in reputed journals and serving as an editorial board member of various repute journals.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7