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Gastric emptying is a complex process that is highly variable and makes the in vivo performance of drug delivery systems
uncertain. To overcome this physiological problem, several different approaches have been proposed to retain the dosage
form in the stomach including bioadhesive systems, single and multiple unit gas generating systems, hollow microspheres,
swelling and expanding systems, floating systems, delayed gastric emptying devices, hydrodynamically balanced systems and
other gastroretentive dosage forms. The principle of buoyant preparation offers a simple and practical approach to achieve
increased gastric residence time for the dosage form, sustained drug release and increased bioavailability. The purpose of this
research was to develop an optimized gastric floating drug delivery system of poorly water soluble drug.
FDDS tablets were prepared, optimized and evaluated for hardness, friability, in vitro buoyancy, in vitro dissolution, drug
content and drug excipients compatibility studies. All the results were within the official limits. Developed formulation exhibited
maximum sustained release with excellent floating properties. Further, the results from floating studies suggested that the desired
floating profile of FDDS could be achieved while maintaining the desirable release properties of the FDDS formulation.
Suryakant Gupta has completed her UG at the age of 21 years from RGPV University and currently student of M. Pharm at BD Sharma University,
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